is acute myelocytic leukemia inherited?
- norton g
momijawea - Leukemia strikes sporadically. Though hereditary influences or environmental exposures may contribute to risk, its occurrence is usually considered random. For some rare families, however, the disease is hereditary. In only a few dozen known cases, parents pass it to their offspring as a single gene.
Genetics (inheritance) has been associated with acute lymphoblastic leukemia (ALL) and chronic myelogenous leukemia (CML), but till now I have not seen any findings that acute myelocytic leukemia (AML) has any genetic (inherited) basis.
- J.S.
It isn't known if AML can be inherited but certain gene mutations that have been observed to correlate with leukemia. I don't know a whole lot about the chronic leukemias or ALL, but since my son is fighting AML leukemia, I have read up on it.
Some genetic mutations that have been seen to be favourable for AML patients include:
- Translocation between chromosomes 8 and 21 (seen in patients with M2)
- Inversion of chromosome 16 (seen in patients with M4)
- Translocation between chromosomes 15 and 17 (seen in patients with M3)
Some genetic mutations that have been seen to be unfavourable for AML patients include:
- Deletion (loss) of part of chromosome 5 or 7 (no specific AML type)
- Translocation between chromosomes 9 and 11 (seen in patients with M5)
- Extra chromosome 8 (no specific AML type)
Leukemia — Comprehensive overview covers symptoms, causes, risk factors, treatment of this blood-related cancer.
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