4/11/11

Myelodysplastic Syndromes & Secondary Acute Myelogenus Leukemia: Directions for the New Millennium (Cancer Treatment and Research)

Myelodysplastic Syndromes & Secondary Acute Myelogenus Leukemia: Directions for the New Millennium (Cancer Treatment and Research)




Myelodysplastic syndromes are to the bone marrow what pneumonia is to the lungs; the response of an organ to a variety of etiologic insults like aging, toxic exposure, infections and auto-immunity. Among infectious causes alone, pneumonia could be the result of a variety of possible pathogens including bacterial, viral, tuberculous or fungal agents. Similarly, MDS cannot be treated as a single disease. Attempts to harness the inherent complexity of MDS by devising `classifications' which group the various syndromes as one disease is as misguided as saying that a pneumonia is not infectious because it did not respond to antibiotics. Progress in the field will occur faster when we re-analyze this premise. Therefore, until a clearer





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