4/17/11

Sons platelet count and wbc are really high, and he isn't sick, any suggestions besides leukemia?


Sons platelet count and wbc are really high, and he isn't sick, any suggestions besides leukemia?
what are some reasons that your platelet count can be really high along with white cell count in a child? red cells are at a fine level, please, only doctors or nurses that are very knowledgeable on lab work
leukemia wasn't ruled out, I would just like to think that isn't what it is. His wbc is at 16.8, that was almost 1 week ago, his platelet count is 586. his pmn is at 10.9 and mono 1.5 if this gives any more info. I'm not a doctor so none of this makes much sense, we go see the doc again tomorrow so i will get more info, i'm just inpatient. He also has frequent headaches and has been wetting the bed.

- Lab Guy
The doctor is better able to answer that question because he has all the information in front of him including a history and physical such as enlarged lymph nodes or enlarged spleen.

You don't give actual counts nor the breakdown of the white cells and so it's hard to comment about how abnormal they. In general platelet counts under 1000 on the report or actually one million if you multiply the units out, is a reactive change commonly seen in inflammation and in bleeding such as with iron deficiency.

With the white blood cells one tries to break it down between reactive benign conditions vs the more serious diagnosis one can not miss such as leukemia (primary hematologic disorder). You mention that leukemia has been ruled out and so one is presumed dealing with reactive disorders. One of the most efficient ways in further characterizing a primary hematologic disorder and a reactive condition is by looking at the blood smear and doing a bone marrow aspirate.

If the examination of the blood smear does not disclose any immature cells then one starts looking at the source of elevation of what type of white cell is causing the elevation. If it's neutrophils then sepsis, infection and inflammation are the primary culprits. One searches for pathognomonic toxic changes in the neurtophils such as vacuoles. If it's lymphocytosis then viral infections are thought of first. With monocytosis then indolent infections with infectious agents such as TB and SBE and chronic inflammation, colitis Crhon's etc are looked at.

One can do sedrates and CRP's in trying to also characterize what is going on. Some conditions for example like lupus give an elevated sedrate but a normal CRP while infection can give high on both. Some viral infections can give mild elevations with the CRP but those over 100 mg/L are usually bacterial. Those are just examples.

There are plenty of pediatric hematologist out there can one can get a second opinion with if it is still cause for concern. Again no counts were given and so it might be a normal variant without any disease. The higher the count is the more one would look into it.

- Joe D
I agree with lab guy. You didn't give the break down of the counts. They can tell most types of leukemia almost immediately because they look at the shape of the WBC under the scope. They should tell you from the lab work about lymphoblasts too- which is present in the majority of leukemias.

How high are the platelets and how high are the wbc? He could have an infection causing the increased counts too- is it like 25++ or like 13++? Big difference in "high" wbc and their implications.... good luck.

Are you following up on u/s of spleen, bone marrow biopsy/aspirate/lumbar puncture?

- Spreedog
You are asking for an expert opinion without giving us the information we need.

I agree with "Lab Guy" and "Joe" - and I'm a hematologist/oncologist MD.
If this is a child - a high platelet count is not suggestive of an acute leukemia.
A reactive or secondary process is more likely. The possible causes are legion.

But you must give us all of the CBC data to get an educated answer.
It would be better if we had the entire medical history and could look at the blood smear ourselves. The doctor seeing your son who has all of the information should be explaining this for you.

- Anne W
i would need to look at the smear and do a flow cell. cant tell from that data.

- adam
find u answer here http://teensandhealth.blogspot.com/2009/03/teens-and-blood-cancers.html

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