What does "mast cell degranulation" means?where can I get more information about it?

What does "mast cell degranulation" means?where can I get more information about it?
I need information about this clinical disorder and what are the potential triggers of mast cell degranulation or mast cell leukemia or mastocytosis. Thanks.

- Bubba13
try www.webmd.com

- chris s
Mast cells are inflammatory immune cells involved in fighting infection and allergies. They release histamine and other inflammatory cytokines, mediators, and hormones. SO they are most famous for releasing histamine, which is active in allergic reactions. Kind of like your body going awry.

Look in Robbins Pathology editor Kumar, Cotran

also Kuby's Immunology text

- quijibored
Mast cell degranulation is where the mast cells break down and release histamine and heparin which then causes all sorts of very unpleasant severe immune and allergic reactions. Mastocytosis is characterized by excessive mast cell infiltration of either the skin or extra cutaneous organs. Death from mastocytosis is secondary to mast cell degranulation.
Read up here about mastocytosis.

http://www.emedicine.com/derm/topic258.htm

http://www.emedicine.com/med/topic1401.htm

http://www.emedicine.com/derm/byname/mastocytosis.htm

- VICAS
hola:
encontre este archivo en español espero te sirva
http://www.smb.org.mx/XXVICONGRESO/text/Carteles/Martes/Ma188.pdf


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