what is the association between chronic myeloid leukemia and myasthenia gravis??
a patient on imatinib for 2 months with a good hematologic response develops myasthenia gravis with positive antiacetylcholine receptor antibodies and no evidence of a thymoma on CT thorax. Could this be due to the disease or could it be due to imatinib induced autoantibodies?? Imatinib is known to produce autoantibodies against muscle and pulmonry interstitium. Or could it be due to leukemia antigen causing an autoimmune response against the myoneural junction??
- Aetherlord
Actually the cause of myasthenia gravis of course like most autoimmune diseases is unknown. There may be a slight chance for surrounding the very cause to be genetic. And most cases are usually best defined with the Thymoma. But you said the patient has CML... The sternum is well known to be part of the hematopoietic function and I am thinking what is the thymus is some how affected or inflicted with a gene from the CML site. Then there is a well connected possibility with the cause of the MG. Imatinib may also be a cause of autoantibodies but for it to be greatly specific is a very rare possibility
Leukemia — Comprehensive overview covers symptoms, causes, risk factors, treatment of this blood-related cancer.
Orignal From: what is the association between chronic myeloid leukemia and myasthenia gravis??
No comments:
Post a Comment