Fanconi anemia is an inherited anemia that leads to bone marrow failure ( aplastic anemia).?
It is an autosomal recessive disorder. It occurs equally in males and females, and found in all ethnic groups; it can affect all systems of the body, and many patients eventually develop acute myelogenous leukemia at an early age; they also develop a variety of other head, neck, gynecological and or gastrointestinal cancers; the patient can be cured of the FA blood problem by having a successful bone marrow transplant, but must still have regular examinations to watch for signs of cancer. A couple (both with FA) who have already had one child with FA decide that they would like to have another child.
a.) What was the genotype of the child with FA?
b.) What is the probability that their next child will have FA?
- jim jones
let the alleles be F for normal allele, and f for the pathological allele.
It's autosomal recessive so you need homozygous alleles to have the disease - i.e. " f f"
if both parents have FA (which I doubt they do), then they are both ff.
The child is ff
and any other children are ff because there's no other possibilities.
so probability = 1
I suspect the mum and dad are heterzygous for the allele, but check your question. In this case, they are both Ff
so the chance of ff is 1/4
and the probability of next child having FA is 1/4
Leukemia — Comprehensive overview covers symptoms, causes, risk factors, treatment of this blood-related cancer.
Orignal From: Fanconi anemia is an inherited anemia that leads to bone marrow failure ( aplastic anemia).?
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